Document in the framework of the BCN'42 project by the group of experts on economic innovation. The reflection in this axis has focused on the initiatives of economic innovation and on the models of the cities: the role of the clusters and the poles of innovation; the relationship between university, business and government, the "Triple Helix"; the society of knowledge, innovation, creativity and starts-up; and the reflection on the frontier of possibility of tourism and the service sector as economic engines of cities.